Lennox- gastaut syndrome is one of the many classifications of epilepsy syndromes. Lennox- gastaut syndrome is serious but it isn’t uncommon. It is defined by three different features: difficult- to- control seizures, mental retardation, and a slow spike- and- wave pattern on the EEG. The seizures experienced by the lennox- gastaut syndrome range between the ages of one through six years old but at times, they can start later on in life. This particular type of epileptic syndrome can involve atypical absence seizures, tonic seizures, myoclonic seizures, and tonic- clonic seizures. These are usually not well controlled. Children who have lennox- gastaut syndrome have mild to severe intellectual impairment and behavioral problems that are a product from the combination of the medications, seizures, and neurological injury.
Medications that are used to treat this seizure disorder are valproate, carbamazepine, clobazam, lamotrigine, topiramate, and zonisamide. For those patients who have seizures that are not under control, they should avoid high doses of many different antiepileptic drugs because they worsen the person’s behavioral, social, and intellectual problems. With surgical treatments, it may be best to look into vagus nerve stimulation and corpus callosotomy. Medical professionals usually perform vagus nerve stimulation before a corpus callosotomy due to the lower risks involved.
Source: “Epilepsy: A Patient And Family Guide” by Orrin Devinsky, MD